• 专利附录
  • 专利说明
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  • 类似技术
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    • 专利摘要:
    Camomile with high chamazulene and bisabolol content is produced from chamomile varity H-29. The chamomile flower heads are pref. harvested at the stage of growth at which only 50% of the tubular florets have opened, the harvested flower heads being dried at an air temp. of not >50 degrees C. The antiinflammatory activity of camomile is attributable to chamazulene and (-)-alpha-bisabolol. Normally, high chamazulene concns. are accompanied by low bisabolol concn. and vice-versa. Surprisingly, chamomile (Matricaria chamomilla) variety H-29 (endemic in the Lerida province of Spain) has high content of both chamazulene and bisabolol, and is partic. suitable for camomile prodn.
    公开号:SU984396A3
    申请号:SU752102789
    申请日:1975-01-22
    公开日:1982-12-23
    发明作者:Исаак Отто
    申请人:Дегусса (Фирма)；
    IPC主号:
    专利说明:

    (54) METHOD FOR OBTAINING PLANT RAW MATERIALS FOR ANTI-INFLAMMATORY MEANS
    The invention relates to the pharmaceutical industry and to the manufacture of medicinal substances. A known method of obtaining an anti-inflammatory substance by drying chamomile flowers. However, the known method does not provide a high content of Chamazulene oL-bizabopol in the substance. The aim of the invention is to increase the content of chamazulene and ob-abolol a. This goal is achieved by drying Matr carla charoomMla Asteraceae H-29 chamomile flowers, collected at the time when 50% of flowers bloom at most, and dried at air temperature not exceeding 50 ° C. When creating certain conditions for harvesting and drying out of chamomile flowers of variety H-29, you can get a high-quality dry mass of chamomile with a Chamazulene content of 150 mg /%, for example, 150-250 mg / and a content of bisabolol of at least 200 mg /, for example 200-300 mg /%. In the inflorescence, the period of complete decay; the "ani of a flower is three weeks. The bloom time covers a period of 50-65 days. It is especially favorable if the harvest time of the variety “-29 passes on the vegetative harvest, i.e. when 50% of tubular flowers opened. When drying, the temperature should not exceed 50 ° C and it is necessary to monitor 3a so that the supply of heat does not exceed the amount that is necessary for complete drying. By controlling weighing, a constant weight is determined. Drying is carried out naturally. or artificially. A high yield of effective substance is obtained by drying under natural conditions, when the sun's rays are avoided. The drying process should occur as soon as possible after harvest. Plants should be dried in a thin layer, for example, 5-20 cm, preferably with a layer thickness of 10 cm. The table shows the change in the content of active substances depending on the development of H-29 plants. Stage I - inflorescence with still missing or directly standing flowers. Stage II - zychkovy flowers nak loneny outside, but tubular flowers did not open yet, Stage II I - tubular flowers from. wings were 50%, the color of the legs was still rounded and filled. Stage IV - inflorescences bloomed to 50-100%. Pedicels are full. No more periodic daily movement of the flowers. Stage V - inflorescences bloomed 100% (full bloom). Stage VI - flowering in the state of flowering. Reed flowers fall down easily. The seeds begin to come down. The determination of the bisabolol content was carried out by gas chromatography method. Determination of chamazulene was carried out spectrophotometrically using a method customary for examining chamomile extracts. Essential oils are separated by distilling water vapor and chamazulene from other substances. In order for the minor losses of azulene to be insignificant, a small amount of ascorbic acid is added during the distillation. From the selected distillate, the essential oils are extracted with petroleum ether or pentane. After distilling off the solvent, the oil content is determined gravimetrically. Chamazulene is determined spectrophotometrically in the resulting oil, bisabolol is determined by gas: romatography. Chamazulene in pharmacy chamomile, obtained by the proposed method, is determined as follows. 6000 g of pharmaceutical chamomile varieties H-29, 50 g each, are combined with 16 liters of water and 150 g of ascorbic acid and distilled in a vessel. Distillate is mixed with 200 ml of Pentane and immediately after that enters the vessel again. The pentane phase is dried over sodium sulfate and evaporated, and the remaining oil is dried on paraffin chips. The resulting pharmacy chamomile (3.9 g) was separated on silica gel M (0.063 to 0.2 mm grain size) with petroleum ether. The strongly cyan-colored fractions, which flow down after passing through the columns, are collected and again chromatographed while observing protection from light. Output; 3.23 g Chamazulene. Isolation of / - / - “I have bizabopola from pharmaceutical chamomile oil, which was obtained from the H-29 chamomile variety. 18 kg of pharmaceutical chamomile varieties H-29 are subjected to exhaustive distillation with water vapor. The oil recovered by petroleum ether is obtained after drying over sodium sulfate by removing the solvent (yield 49 g). 30 g of chamomile oil is dissolved in a double volume of benzene and isolated on silica gel with a G-Merck column (600 g) with benzene and eluted. A 25 ml portion of the eluate was continuously fractionated, and a thin layer chromatogram was obtained from each fourth fraction. Fractions 164-320, containing bisabolol, were isolated (Ul, 3 g) and the G-Merek columns (425 g) were again fed to silica gel (benzene) and eluted. Of all 608 fractions, 212-288 contains 2.4 g of pure bisapolol.
    Example. Getting pharmacy chamomile with a high content of hamaeulen and bisabolol.
    An H-29 chamomile variety derived from Llanos de Urgel is sown in the usual way on the field. Once the plants have developed and about 50% of the tubular flowers have opened, the flowering heads are picked with a special chamomile machine. The harvested crop is transported as quickly as possible to a protected shady place and distributed in a thin layer there. Immediately after this, the heads of flowers are freed from the sieve from the stems and dried to a constant weight. Weight loss is approximately 85%. Drying occurs in the shade in a well-ventilated place in a layer thickness of approximately 10 cm.
    After 2-3 days, drying is completed. To remove parts of the stems and flower debris, the pharmacy chamomile is sifted and immediately pressed into bales. Analysis, mg /%: essential oil 900, chamazulene 175 :, / - / -oi bisabolol 245.
    The proposed method provides anti-inflammatory substances with a high content of chamazulene and bioebole.
    权利要求:
    Claims (1)
    [1]
    1. Turov A.D. Medicinal rasos shadows of the USSR and their application. M., 1967, p. 406.
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    同族专利:
    公开号 | 公开日
    IT1035096B|1979-10-20|
    ATA42575A|1978-04-15|
    DE2402802A1|1975-07-24|
    DE2402802B2|1978-10-19|
    PL114331B1|1981-01-31|
    CS190444B2|1979-05-31|
    ES8705741A1|1986-06-16|
    AT347030B|1978-12-11|
    DE2402802C3|1979-06-13|
    引用文献:
    公开号 | 申请日 | 公开日 | 申请人 | 专利标题
    DE3441754C2|1983-06-29|1996-10-17|Asta Medica Ag|Production of camomile extracts and essential oil from tetraploid camomiles according to German patent 34 23 207|
    DE3423207C3|1983-06-29|1996-09-26|Asta Medica Ag|Process for producing a new type of chamomile |
    IT1177840B|1983-06-29|1987-08-26|Degussa|PROCESS FOR THE PRODUCTION OF A CHAMOMILE|
    IN163594B|1984-03-16|1988-10-15|Degussa|
    MX161477A|1984-09-19|1990-09-28|Degussa|PROCEDURE FOR REMOVING THE CONSTITUENTS OF CHAMOMILE|
    RU1836004C|1984-12-19|1993-08-23|Аста Медик Аг|Method of obtaining tetraployde matricarium camomilla recutital, acteraceae|
    DE3446222C2|1984-12-19|2003-06-26|Viatris Gmbh|Process for the production of new chamomile products with improved properties|
    DE3446217C2|1984-12-19|1994-05-19|Degussa|Process for the preparation of a new antiphlogistic agent|
    DE3542756C3|1984-12-19|1997-09-04|Asta Medica Ag|Process for the preparation of a new tetraploid and bisabolol-rich chamomile with improved properties|
    US6300370B1|1987-02-13|2001-10-09|Asta Medica Aktiengesellschaft|Camomile oils having a high content of natural poly-ynes and process for their preparation|
    EP0285752B1|1987-02-13|1993-10-27|ASTA Medica Aktiengesellschaft|Camomile oils having a high natural polyine content, and process for their production|
    DE3806210A1|1988-02-26|1989-09-07|Robugen Gmbh|CHAMOMILE|
    法律状态:
    优先权:
    申请号 | 申请日 | 专利标题
    DE2402802A|DE2402802C3|1974-01-22|1974-01-22|Obtaining a chamomile drug with a high content of chamazulene and bisabolol|
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